DeMar DeRozan scored 25 points to lead the Spurs to a 116-110 win over the Cavaliers on Manu Ginobili jersey retirement night in San Antonio.
Bryn Forbes added 19 for San Antonio, which used a 40-point third quarter to take command. Marco Belinelli added 16 off the bench for the Spurs, who have won two of their last three.
Collin Sexton led the Cavaliers with 24 points. Kevin Love added 18 for Cleveland, which has lost four straight.